How Often Should You Inject NAD+? Dosing Schedule Guide

NAD+ Injection Frequency: What the Evidence Suggests

There is no universally standardized dosing protocol for subcutaneous NAD+ injections — unlike prescription medications approved through a formal clinical trial program, NAD+ therapy relies on clinical experience, practitioner guidelines, and patient response to determine optimal frequency. That said, consistent patterns have emerged from clinical practice that inform the approach Tmates' doctor-supervised program's physicians take with NAD+ injectable therapy ($149/mo).

Loading phase (first 4–8 weeks): Many protocols start with higher frequency — 3–5 injections per week — to rebuild significantly depleted NAD+ pools faster and produce earlier symptomatic improvement. This loading approach rapidly restores intracellular NAD+ to adequate levels, allowing patients to experience the energy, cognitive, and recovery benefits that motivate continuation. The clinical reasoning: significantly depleted pools benefit from aggressive restoration before transitioning to maintenance.

Maintenance phase (after initial restoration): Once NAD+ pools are adequately restored — typically indicated by stable symptom improvement around 4–8 weeks — most protocols transition to 1–3 injections per week as a maintenance dose. The goal is to maintain elevated NAD+ levels rather than continuing to rapidly restore them, requiring less frequent dosing. Some patients sustain adequate NAD+ levels on as few as 2 injections per week; others find 3 per week optimal for sustained energy and cognitive performance.

Your Tmates physician determines the appropriate starting frequency and transition timing based on your health history, symptom severity, age, and response to treatment. Progress check-ins allow adjustment of frequency as your response develops. See NAD+ injection benefits, delivery method comparison, nasal spray vs injection, and the full anti-aging category including Sermorelin.